The Remarkable Link Between Intense Exercise and Parkinson's Progression.
Learn the benefits of intense exercise for people with Parkinson's disease. A recent study found that people with Parkinson's disease who engaged in intense exercise for 12 weeks had slower rates of progression of the disease than those who did not exercise. Exercise helps to protect the brain from damage and improve balance, coordination, and mobility. Talk to your doctor about the benefits of exercise for Parkinson's disease.
Dr.DIDWAL MD
7/18/20235 min read
Neuroscientists have made a groundbreaking discovery in the realm of Parkinson's disease management. Their research reveals that intensive exercise holds the key to slowing down the progression of this debilitating neurological condition. This new understanding sheds light on previously unexplored mechanisms and opens up possibilities for novel non-pharmacological treatments. Let's delve into the study's findings and explore the remarkable link between intense exercise and Parkinson's progression
New Insights in Parkinson's Research
A collaborative effort between the Faculty of Medicine at the Catholic University, Rome Campus, and the A. Gemelli IRCCS Polyclinic Foundation has led to a significant breakthrough. Their research indicates that engaging in intensive exercise can decelerate the advancement of Parkinson's disease. Moreover, the study delves into the underlying biological mechanisms that support this phenomenon, offering potential pathways for developing non-drug interventions
Study Details and Funding
Published in the prestigious journal Science Advances, the study titled "Intensive exercise ameliorates motor and cognitive symptoms in experimental Parkinson's disease by restoring striatal synaptic plasticity" involved various institutions, including the San Raffaele Telematic University Rome, CNR, TIGEM, University of Milan, and IRCCS San Raffaele, Rome. The research received funding from the Fresco Parkinson Institute, New York University School of Medicine, The Marlene and Paolo Fresco Institute for Parkinson's and Movement Disorders, the Ministry of Health, and MIUR. These resources empowered scientists to explore the beneficial effects of exercise on brain plasticity in unprecedented ways.
A New Mechanism Unveiled
Professor Paolo Calabresi, a leading Catholic University neurologist and Director of the UOC Neurology at the University Polyclinic A. Gemelli IRCCS, expressed excitement over discovering a previously unknown mechanism. The research demonstrated how exercise, particularly in the early stages of Parkinson's disease, induces lasting positive effects on movement control, even after the training period ends. This groundbreaking revelation lays the groundwork for the development of complementary non-pharmacological treatments to enhance existing drug therapies.
Building on Previous Knowledge
Prior studies have hinted at the connection between intensive physical activity and the brain-derived neurotrophic factor (BDNF), a critical growth factor. The recent research successfully replicated this phenomenon using a four-week treadmill training protocol in an animal model with early-stage Parkinson's. For the first time, the study establishes how BDNF contributes to the brain's beneficial response to physical activity.
Unlocking the Neuroprotective Effect
Drs. Gioia Marino and Federica Campanelli, researchers at the Faculty of Medicine, Catholic University, Rome, employed a multidisciplinary approach to demonstrate the neuroprotective effect of exercise. Their investigation involved various techniques to measure improvements in neuronal survival, brain plasticity, motor control, and visuospatial cognition.
The researchers found that daily treadmill training sessions notably reduced the spread of pathological alpha-synuclein aggregates. In Parkinson's disease, these aggregates cause progressive dysfunction of neurons in crucial brain regions responsible for motor control, namely the substantia nigra pars compacta and the striatum.
Key to Neuronal Survival
The neuroprotective effect of intensive exercise lies in promoting the survival of neurons that release the neurotransmitter dopamine. This survival is essential for the expression of dopamine-dependent plasticity in striatal neurons, which the disease would otherwise impair. As a result, intensive training preserves motor control and visuospatial learning, both dependent on nigrostriatal activity.
Moreover, the study reveals the interaction between BDNF and the NMDA receptor for glutamate. This interaction empowers striatal neurons to respond effectively to stimuli, leading to enduring effects that extend beyond the exercise period.
Future Implications and Ongoing Research
Professor Paolo Calabresi disclosed that their research team is actively engaged in a clinical trial to assess whether intensive exercise can serve as a tool for identifying new markers to monitor the disease progression in early-stage patients. The research also explores the role of glial cells, specialized groups of cells providing support to neurons and their environment. Understanding the molecular and cellular mechanisms behind the observed beneficial effects will shape future approaches in Parkinson's disease management
, The remarkable link between intense exercise and Parkinson's progression marks a significant step forward in our understanding of this complex neurological condition. The neuroprotective effects of exercise offer hope for enhanced treatment strategies and improved quality of life for those living with Parkinson's. As research continues to unfold, this newfound knowledge paves the way for a brighter future in the fight against Parkinson's disease.
How does intensive exercise slow down Parkinson's progression?
Intensive exercise can slow down Parkinson's progression through several mechanisms. Firstly, it promotes brain plasticity, which allows the brain to adapt and repair itself. Secondly, it increases the production of brain-derived neurotrophic factor (BDNF), a vital growth factor supporting neurons' survival. This enhanced neuronal survival is crucial for maintaining motor control and cognitive function, both of which are affected by Parkinson's disease. Additionally, intensive exercise reduces the spread of pathological alpha-synuclein aggregates, which contribute to the dysfunction of neurons in key brain regions responsible for movement. Overall, the combination of these effects helps to slow down the advancement of Parkinson's.
What are the key findings of the study on Parkinson's and exercise? The key findings of the study on Parkinson's and exercise were significant. The research demonstrated that engaging in intensive exercise can ameliorate motor and cognitive symptoms in experimental Parkinson's disease. It revealed a never-before-seen mechanism through which exercise induces beneficial effects on movement control, even lasting after the training period ends. The study also highlighted the role of brain-derived neurotrophic factor (BDNF) in supporting the brain's positive response to physical activity. Moreover, daily treadmill training sessions were found to reduce the spread of pathological alpha-synuclein aggregates, providing evidence of exercise's neuroprotective effect.
Can non-pharmacological treatments be as effective as drug therapies for Parkinson's?
Non-pharmacological treatments, including intensive exercise, have shown great promise in complementing drug therapies for Parkinson's. While medications play a crucial role in managing symptoms, non-pharmacological interventions offer additional benefits. Intensive exercise has been found to slow down the progression of the disease, improve brain plasticity, and enhance neuronal survival. When used in combination with drug therapies, non-pharmacological treatments can lead to more comprehensive and effective management of Parkinson's disease, ultimately improving the patient's quality of life.
How can patients incorporate intensive exercise into their daily routines?
With healthcare professionals ' guidance, patients can incorporate intensive exercise into their daily routines. Tailoring the exercise regimen to the individual's specific needs and abilities is essential. Consultation with neurologists, physical therapists, or exercise specialists is crucial to designing a safe and effective exercise plan. Intensive exercise may include activities like high-intensity interval training, strength training, or cardiovascular exercises. Starting slowly and gradually increasing the intensity is recommended, ensuring the exercise routine is manageable and enjoyable
What are other measures that are helpful?
a. Diet and Nutrition: A balanced and nutritious diet, rich in antioxidants and anti-inflammatory foods, may support brain health and overall well-being.
b. Complementary Therapies: Therapies like yoga, music therapy, and meditation have shown positive effects in reducing stress, improving mobility, and enhancing emotional well-being.
c. Supportive Network: Building a strong support system with family, friends, and support groups can help patients cope with the challenges of Parkinson's and foster a positive outlook.
d. Mental and Emotional Wellbeing: Addressing mental health through counseling or therapy can contribute to better emotional resilience and quality of life.
e. Innovative Technologies: Advancements in wearable technology and virtual reality have the potential to enhance rehabilitation and promote better motor function.
Combining these non-pharmacological interventions with traditional drug therapies can lead to a holistic approach to Parkinson's management, offering comprehensive support and improved outcomes for patients.
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